Sunday 9 November 2014

Mole Hunting

The law of conservation of mass
This law states that in a reaction, the total mass of the reactants and the total mass products will be the same. Therefore, no mass is lost or created during a reaction, hence it is conserved. So for example, if calcium carbonate is thermally decomposed to give 28 grams of calcium oxide and 22 grams of carbon dioxide, then the initial amount of calcium carbonate would be exactly 50 grams (assuming that no reactants escaped and the reaction was perfect). Here are some reasons as to why this phenomenon may not always be observed:
  • reversible reactions may not go to completion
  • some product may be lost when it is removed from the reaction mixture
  • some of the reactants may react in an unexpected way


Antoine Lavoisier is credited for writing the law of conservation of mass. He wrote:
"Nothing is created, either in the operations of art or in those of nature, and it may be considered as a general principle that in every operation there exists an equal quantity of matter before and after the operation; that the quality and quantity of the constituents is the same, and that what happens is only changes, modifications. It is on this principle that is founded all the art of performing chemical experiments; in all such must be assumed a true equality or equation between constituents of the substances examined, and those resulting from their analysis."


However, many scientists had already outlined the ideas of The Law of Conservation of Mass before, but he did independently discovered it and wrote, researched and taught the law the most extensively.  


Pre-history leading up to Lavoisier
Anaxagoras in 450 B.C. said:
"Wrongly do the Greeks suppose that ought begins or ceases to be; for nothing comes into being or is destroyed; but all is an aggregation or secretion of pre-existing things; so that all becoming might more correctly be called becoming mixed, and all corruption, becoming separate."


Around 1623, Francis Bacon wrote:
"Men should frequently call upon nature to render her account; that is, when they perceive that a body which was before manifest to the sense has escaped and disappeared, they should not admit or liquidate the account before it has been shown to them where the body has gone to, and into what it has been received."


Joseph Black made extensive studies of the carbonates of the alkali and alkaline earth metals, and while doing so, he noted that the additional mass of the product was probably because the reactants were reacting with air too. Therefore, he hinted that the mass of the reactant should be the same as the mass of the products, in a perfect experiment. Henry Cavendish was also a scientist who seems to have had an understanding of the Law of Conservation of Mass but did not explicitly state it.    


When John Dalton came up with his atomic model, he theorised that all atoms of a given element are identical in mass and properties and a chemical reaction is a rearrangement of atoms. What we can conclude from his findings is that mass of a certain amount of an element/molecule/compound can be calculated because atoms of a given element are identical in mass and that all matter is conserved in a reaction.


The Avogadro's number is the number of atoms of an element that is weighs the relative atomic mass of the element in grams. The Avogadro number is named after Amedeo Avogadro, who in   1811 first proposed that the volume of a gas (at a given pressure and temperature) is proportional to the number of atoms or molecules regardless of the nature of the gas. The value of Avogadro's number is 6.022 × 1023 mol−1. Avogadro never actually calculated the number himself, but he did suggest, but Loschmidt was the first scientist, who we know of, to have suggested it, so the number, which it discoverer Jean Perrin proposed to be named after Avogadro, should be named after Loschmidt.  


A modern definition of mole is:
“... as the amount of substances of a system that contains as many “elemental entities” (e.g. atoms, molecules. ions, electrons) as there are atoms in 12 g of carbon-12.


What this definition means is that as 6.022 × 1023 mol−1 of carbon-12 is 12 g, just as a mol of hydrogen-1 is 1 g and a mole of oxygen-16 is 16 g. A mole is defined as this because 1 Ar is defined as 1/12 of carbon-12 relative atomic mass.  


So to summarise:
1 gram  =  1 mole of amu
therefore
1 gram = 6.022 × 1023 mol−1  amu
      

Friday 21 February 2014

Coronary heart disease


Introduction to the heart
The structure and function of the heart
  1. Pulmonary valve → this valve restricts blood flow between the  right ventricle and the pulmonary artery
  2. Pulmonary arteries → this arteries carries deoxygenated blood from heart to the lungs
  3. Right atrium - it is one of the four chambers in the heart, which receives deoxygenated blood from the inferior vena cava and the superior vena cava, and pups the blood into the right ventricle through the tricuspid valve
  4. Right ventricle → it is one of the four chambers in the heart. It is situated below the right atrium, and it receives deoxygenated blood from the right ventricle through the tricuspid valve (as seen before) and pumps the deoxygenated blood pulmonary artery through the pulmonary trunk (not labelled).
  5. Aorta → this is the largest (i.e. it is the artery with the biggest diameter) in human body. The aorta stretches from the left ventricle to the abdomen
  6. Pulmonary veins → these veins carries oxygenated blood from lungs to the hearts
Inside the heart, there are four chambers/cavities fill with blood. Two of these cavities are called atria. The other two are called ventricles. The two atria are situated at the top of the heart (as seen in the diagram). The ventricles are situated at the bottom of the heart. The left ventricle contracts most forcefully because it needs to pump blood around the body, whereas the right ventricle only needs to pump blood to the lungs.  so you can best feel your heart pumping on the left side of your chest. That is why the wall of the left ventricle is thicker than of the right ventricle. Each side of the heart houses one ventricle and one atrium. A wall, called the septum, separates the right and left sides of the heart. A valve connects each atrium to the ventricle below it. The mitral valve connects the left atrium with the left ventricle. The tricuspid valve connects the right atrium with the right ventricle.Now, lets look at the heart as a whole. Many large vessels are connected to the top of the heart. One of the vessels is the largest artery (in the body), called the aorta, which carries nutrient-rich blood away from the heart. Another important vessel is the pulmonary artery which connects the heart with the lungs as part of the pulmonary circulation system. The two largest veins that carry blood into the heart are the superior vena cava and the inferior vena cava. They are called "vena cava" because they are the "heart's veins." The superior is located near the top of the heart. The inferior is located beneath the superior. The heart's structure makes it an efficient, never-ceasing pump. From the moment of the heart appears in our body (when we are a fetus) till the moment we die, the heart pumps constantly. The heart, therefore, has to be strong. The average heart's muscle, called cardiac muscle, contracts and relaxes about 70 to 80 times per minute involuntarily (you don’t need initiate the action). As the cardiac muscle contracts it pushes blood through the chambers and into the vessels. Nerves connected to the heart regulate the speed with which the muscle contracts (these nerves regulate the pacemaker cells). The heart is split into two different parts, the right side and the left side. The right side of the heart receives deoxygenated (blood with low levels of oxygen) blood from the body tissues (the blood from the upper part of the body is received by Superior Vena Cava whereas the blood from the lower part of the body is received from the Inferior Vena Cava) into the right atrium. This deoxygenated blood passes through the tricuspid valve into the right ventricle. This blood is then pumped under higher pressure from the right ventricle to the lungs via the pulmonary artery The left-hand side of the heart receives oxygenated blood from the lungs (via the pulmonary veins) into the left atrium. This oxygenated blood then passes through the bicuspid valve into the left ventricle. It is then pumped to the aorta under greater pressure.This higher pressure ensures that the oxygenated blood leaving the heart via the aorta is effectively delivered to other parts of the body via the vascular system of blood vessels.    

Coronary heart disease So what is Coronary Heart Disease, why does it happen and what are the risk factors?Coronary heart disease(sometimes abbreviated as CHD)is also known as atherosclerotic heart disease or ischemic heart disease. CHD is the most common type of heart disease and cause of heart attack. This disease is caused by the build-up of fatty material, which obstructs the flow of blood to the heart, building up in the wall of the coronary arteries. This is detrimental to the health of the heart because heart needs a constant supply of blood for muscle contraction to happen, which requires cells to respire, and without enough supply of blood, the cell that make up the heart will not be able to respire as fast as they should. As the fatty deposits builds up, the inner lining of the coronary arteries slowly become filled with substance called plaque, which is formed from cholesterol. This process of fat clogging up in coronary arteries is called atherosclerosis. Not only does the plaque narrow the coronary arteries, but also it block nutrients being delivered to the artery walls, which means the arteries lose their elasticity. In turn, this can lead to high blood pressure, which also increases the risk of heart disease. This same process goes on in the arteries throughout the body, and can lead to high blood pressure which puts further strain on the heart. Some people who have CHD have it because of genetic factors - which made them more vulnerable to atherosclerosis. A clue to know if one has a higher risk of getting CHD is by checking family history of heart disease in middle-age. Genetic factors are not the only reason one might develop, lifestyle factors (environmental factors) also increase the risk include an unhealthy diet, lack of exercise, diabetes, stress, obesity/overweight, high blood pressure and, most importantly, smoking. Also, some research suggest that gender and age may affect the probability of one getting CHD. Historically, men were thought to have more chance getting CHD than women, but in recent years, CHD has claimed women and men in nearly equal numbers.
The symptoms of CHDAs discussed earlier, coronary heart disease happens when a plaque forms in the arteries (called coronaries) that deliver blood to the heart. If the arteries are partially blocked (meaning that the plaque does not completely clog-up the artery’s cavity), the person with CHD could experience angina. Angina is severe chest pain that can spread across the upper part of the body because the heart experiences difficulties while trying to pump blood around the body without adequate supply of oxygen. Angina is the most common symptom of CHD. When one’s artery becomes completely blocked with plaque, he/she gets a heart attack. During a heart attack, one can experiences these symptoms:
  • sweating
  • light headedness
  • nausea
  • breathlessness
How can CHD be preventedAs discussed before, some risk factors of CHD can be controlled. The first step one can take to prevent CHD is to exercise and follow a healthy diet/balanced diet. Specifically, one needs to eat:
  • vegetables
  • fruits
  • whole grains
  • fat-free (or low fat) dairy products
  • food high in unsaturated fat which help us to reduce our cholesterol - e.g. oily fish (cod), avocados, sunflower, rapeseed, olive and vegetable oils.   
  • protein food
  • seafood
  • processed soy products
  • nuts
  • seeds
  • beans
  • peas
  • less sugary foods  
A good diet is important because it keeps our blood pressure under control. Furthermore, obesity affects the risks of CHD, so if a person is obese, he or she needs to go to the doctor to create a reasonable weight-loss plan. Quitting smoking also helps. Smoking can damage and tighten the blood vessels in our body. If there is a family-history of problems with CHD, one may need to go to the doctor. Sometimes, controlling lifestyle choices may not be enough, one may need to take medicine that have been prescribed to them by doctor to mitigate the risk of having CHD.   


Tuesday 4 February 2014

What can the Periodic Table tell us about everyday chemicals


The periodic table and its structure
  
              





Periods - the rows of the periodic table are arranged in what we call periods. The periodic table has seven periods in total. Period 1 contains only two elements: hydrogen and helium. Period 6 (including the lanthanides) contains 32 elements and so it contains more elements than any other period. The period can tell us how many shells a element has, so elements in period 1 will have one shell.


Each period begins with an alkali metal and ends with a noble gas, though period 7 is not complete; it is predicted that there is a noble gas with a atomic number of 118 (its current chemical formula is Uuo) but this element’s existence has not been proven yet.


As you go across a period, the number of electrons in the outer shells starts to increase. For example, in period 2, Li (lithium) has one electron in its the outer shell, B (boron) has 3 electrons in the outer shell and Ne (neon) has 8 electrons in the outer shell.  


Groups - this is the name given to the vertical columns of the periodic table. Elements in a group share many common properties. All the elements in a certain group have the same number of electrons in the outer shells. The outer electrons are called valence electrons. Because they have the same number of valence electrons (number of electrons in the outer shell), elements in a group share similar chemical properties. The Roman numerals listed above each group are the usual number of valence electrons.


Details on specific elements   
Chlorine
The periodic table tells us that chlorine(Cl) can be found in 3rd period and the 7th group. The element is situated at the far right side of the table (so it is a nonmetal). It has a relative atomic mass of 35.45 AMU (atomic mass unit). Chlorine is a halogen (because it is in the 7th group) and has two stable isotopes (explained later). Chlorine is gas at room temperature.  Its electronic structure is 2.8.7. Its atomic number is 17.


Appearance and properties - Chlorine is greenish-yellow, irritating and toxic gas with a choking smell. Its properties are:
  • It has a melting point of -100.98°C
  • Its boiling point is -34.6°C
  • Chlorine is in many reactions, particularly in substitutions with hydrogen.
  • The gas irritates respiratory and other mucous membranes.\
  • Chlorine in liquid form is corrosive and so will burn the skin.
  • Humans can smell as low an amount as 3.5 ppm(parts per million). As chlorine is toxic, few breaths at a concentration of 1000 ppm is usually fatal.
  • As a gas, chlorine is a diatomic molecule (Cl2) which means that there is two chlorines in each molecule of chlorine.
This is the electron shell configuration of Chlorine.


Uses - Chlorine is widely used in many different areas. It was used as a weapon during the First World War (to poison the enemy by having gas attacks). The gas is made on a large scale from the electrolysis of table salt (sodium chloride)/sylvite (KCl) or the evaporation of water from salt water. Furthermore, it is used to manufacture consumer products such as paper, dyestuffs, textiles, petroleum products, medicines, antiseptics, insecticides, foodstuffs, solvents, paints and plastics. It is also used to make important chemicals such as chlorates, chloroform, carbon tetrachloride and bromine. A extra use for this element is in organic chemistry, both as an oxidising agent and in substitution reactions. It is also used to purify drinking water and to disinfect swimming pools and drinking water. Our daily intake is about 6g, mainly in the form of salt.


Reaction and uses of its compounds:
Chlorine is used to make Table salt (NaCl). The reaction to make table salt is as follows:
2Na + Cl2 → 2NaCl
  
Also, Chlorine is used to make a chemical compound called chloroform  - a strong liquid (CHCl3) which, when vapors are inhaled, causes strong anesthetic effects. Chloroform is thought to be carcinogenic, toxic to the heart and liver. Abuse can cause sudden death.
To make chloroform, bleach is mixed with acetone/alcohol. The reaction is:
NaClO  + C3H6O →  CHCl3 + 2 NaOH + CH3COONa  


Health and safety:
As chlorine is toxic, few breaths at a concentration of 1000 ppm is usually fatal. So it is important that any reaction done using chlorine is done in a fume cupboard. Also bleach (a product of chlorine) vapours are toxic so nasal masks should be used when working with bleach. Chlorine can burn skin and so gloves should be used when working with products with high concentrations of chlorine.


Isotopes:
In total, the total number of chlorine isotopes are 16, with atomic mass ranging from 31 - 46. Out of all the isotopes, chlorine has two stable isotopes: Cl-35 and Cl-37 with Cl-35 as the most abundant form (75.8%). That is why the relative atomic mass of Chlorine is 35.453 AMU.


Stable isotopes are those that do not have an half life/ decay i.e. they do not split into 2 periodically. The amount of these isotopes in the earth remains the same.


Unstable isotopes are the isotopes are the opposite. They have half life; they decay so they half every few years.


Extra information:
  • Chlorine leaks in containers are detected using ammonia. Ammonia will react with the chlorine and form a white mist above the leak.
  • The most common natural chlorine compound on Earth is sodium chloride or table salt.
  • Chlorine is the 21st most abundant element in the Earth's crust
Copper
The periodic table tells us that copper(Cu) can be found in 4th period and the 11th group (not shown in periodic table in first page). The element is situated at the centre side of the table (so it is a metal). It has a relative atomic mass of 63.546 AMU (atomic mass unit). Its atomic number is 29. Copper is a transition metal (because it is in the 11th group). Copper is solid at room temperature.  Its electronic structure is 2.8.18.1.


Appearance and properties
Copper is a very shiny metal. It has an orange-gold colour. It is a really good conductor of electricity, second only to silver. it doesn't corrode easily and is relatively cheap since its very abundant in the earth’s crust. Also, copper is very malleable (can be hammered into shape) and is very ductile (can be drawn into wires) and so it is used in water tubes and electrical conductors.


More properties:
  • Melting point - 1083.040K.
  • Boiling point - 25670K


Uses:
One of the main of uses of copper is its use in the electrical industry. Copper is used to make components, wires… Copper is used in plumbing; it is used to make water tubes. Copper is used to make cookware e.g. bottom of frying pans because it is a good conductor of heat. Copper is used in pesticides (chemicals that kills insects or other organisms harmful to cultivated plants or to animals.) Many coins contain copper.


Isotopes:
There are 28 known isotopes of copper with atomic mass ranging from 53 to 80 AMU. There are two stable isotopes: Cu-63 (69.15% abundance) and Cu-65 (30.85% abundance).


Health and safety:
Copper is non-toxic. So coming with contact with copper is dangerous. We intake copper into our body through food and water. Copper is good for our health, so sufficient amounts of copper is needed to be consumed each day. Exposure to copper often occurs. In the working environment, copper contagion can lead to a flu-like condition that is known as metal fever. This condition passes in about two days and is caused by over sensitivity.


Reactions of copper and its compounds:
4Cu + O2 → 2Cu2O
Cu + F2 → CuF2
Cu + Cl2 → CuCl2
Cu + Br2 → CuBr2
Other very interesting facts about copper:
  • The history of the use of copper extends to the ancient times. Historians even call the period of time between the Neolithic and Bronze Ages the Copper Age.
  • Some interesting chemistry:
  • Copper(I) burns blue in a flame test.
  • Copper(II) burns green in a flame test.
  • Copper's atomic symbol Cu is derived from the Latin term 'cuprum' meaning 'metal of Cyprus'.
  • An interesting use of copper sulfate compounds is that such compounds are used to prevent fungus and algae growth in standing water supplies such as ponds and fountains.
  • Copper is a red-orange metal that darkens to a brown color as it is exposed to air. If it is exposed to air and water, it will form a verdigris of blue-green.
  • Copper sheets were added to the bottom of ships to prevent 'biofouling' where seaweed, and barnacles would cling to ships and slow the ships down. Today, copper is mixed into the paint that is used to paint the underside of ships.


Carbon
The periodic table tells us that carbon(C) can be found in 3th period and the 4th group. The element is situated at the right side of the table (so it is a non-metal). It has a relative atomic mass of  12.011 AMU (atomic mass unit). Its atomic number (as shown in the periodic table) is 16. Carbon is solid at room temperature.  Its electronic structure is 2.4.


Appearance and properties
Carbon can be found in three different forms; amorphous (lampblack, bone black), graphite, and diamond. This forms are called the allotropic forms of carbon. But, normally, carbon is found as amorphous (lampblack, bone black)).  


Uses:
Carbon is used to make numerous and varied amounts of compounds with limitless applications. Many thousands of carbon compounds are integral to life processes (carbon is one of the most abundant elements in our body).


Diamond is bought as a gemstone (because of its attractiveness) and is used for cutting and drilling(as it is one of the most hardest substances in the earth and diamond can be made very sharp).


Carbon as graphite is used for melting metals, in pencils, for rust protection; for lubrication; and as a moderator for slowing neutrons for atomic fission. Amorphous carbon is used for removing tastes and odors. Carbon as coal is also used as a fuel supply (in power stations, coal-fired trains etc).. Melting point of carbon is 3820 0K and its boiling point is 5100 0K.


Reactions of carbon and its compounds:
C + O2 → CO2
C6H12O6 + O2 → CO2 + H2O  (aerobic respiration reaction)
CO2 + 12 H2O → C6H12O6 + 6 O2 + 6 H2O   (photosynthesise reaction)
Oxygen
The periodic table tells us that oxygen(O) can be found in 3th period and the 6th group (not shown in periodic table in first page). The element is situated at the centre side of the table (so it is a metal). It has a relative atomic mass of 63.546 AMU (atomic mass unit). Its atomic number is 29. Oxygen is a gas at room temperature.  Its electronic structure is 2.6.  


Appearance and properties:
Oxygen gas is colorless, odorless, and tasteless. The liquid and solid forms are a pale blue color and are strongly paramagnetic (polar). Oxygen lets combustion takes place, combines with most elements (i.e. oxidises most elements), and is a component of hundreds of thousands of organic compounds. Ozone, a compound of oxygen, protects humans by acting as a UV light barrier.


Uses:
Until 1961, oxygen was used as the atomic weight standard (1/16th of a mole of oxygen was 1 AMU. Mole is a unit that is used to quantify the mass of elements) but  International Union of Pure and Applied Chemistry adopted carbon 12 as the new basis. As oxygen is the third most third most abundant element found in the sun and the earth, it plays a part in the carbon-nitrogen cycle. Oxygen enrichment of steel blast furnaces accounts for the greatest use of the gas.


Large quantities of oxygen are used in making synthesis gas for ammonia, methanol, and ethylene oxide. It is also used as a bleach, for oxidizing oils, for oxy-acetylene welding, and for determining carbon content of steel and organic compounds. Plants and animals require oxygen for respiration. Hospitals frequently prescribe oxygen for patients. Approximately two thirds of the human body and nine tenths of the mass of water is oxygen.     


  • Density (g/cc): -183°C)
  • Melting Point: 54.8 0K
  • Boiling Point: 90.19 0K


Argon
Argon is inert (inactive) and so hence its name (argon if inactive in greek).  Argon has a freezing point of -189.2°C, boiling point of -185.7°C, and density of 1.7837 g/l. Even though argon is a noble gas, it does form a hydrate with a dissociation pressure of 105 atm at 0°C. Argon is two and a half times more soluble in water than nitrogen, with approximately the same solubility as oxygen. It is a gas in room temperature.  It is a non-metal.
Uses:
Argon is used in electric lights and in fluorescent tubes, photo tubes, glow tubes, and in lasers. Argon is used as an inert gas for welding and cutting, blanketing reactive elements, and as a protective (non-reactive) atmosphere for growing crystals of silicon and germanium.


Health and safety:

Argon is an inert gas. It is non-toxic and can only present a problem if it displaces air (or the oxygen in air). This may lead to suffocation. As long as there is "enough" oxygen in the air for breathing, argon will not be harmful.